14 Then the Lord said to Moses, “Write this on a scroll as something to be remembered and make sure that Joshua hears it, because I will completely blot out the name of Amalek from under heaven.”
15 Moses built an altar and called it The Lord is my Banner. 16 He said, “Because hands were lifted up against the throne of the Lord, the Lord will be at war against the Amalekites from generation to generation.” Exodus 17:14-16
If you recall, Amalek was the grandson of Esau. Esau was Jacob’s rotten brother. They were sworn enemies.
This was the first of many battles Israel would fight against the Amalekites.
The Lord wanted Joshua, Moses’ successor, to remember this event as well.
At this point in Israel’s history, it would be nearly impossible to turn the Lord’s mind in favor of the Amalekites.
Jacob I loved; Esau I hated. Malachi 1:3
May nations serve you and peoples bow down to you. Be lord over your brothers, and may the sons of your mother bow down to you. May those who curse you be cursed and those who bless you be blessed. Genesis 27:29
God obviously favored Jacob/Israel over Esau and his lineage. Even though the Lord did bless Esau with a great nation, Esau wasn’t the favored child.
In life we will have enemies even if we’d rather not. People just rub us the wrong way (and we probably rub others the wrong way too). It’s a fact of life even if we deny it.
Of course the Biblical way of handling it is “If it be possible, as much as in you lieth, be at peace with all men,” Romans 12:8. If you’ve done your utmost and it still fails, part ways gracefully.